Yes you can take 5-htp with B6...almost all natural meds for anxiety and depression are recommened to be taken with B6 because B6 aids in all of these crossing the blood brain barrier easier. Don't over do B vitamins because they can cause a rise in heart rate which in turn can start a panic attack. They say depression comes first then anxiety but soem say opposite. I never had depression that brought on anxiety...but after having anxiety for so long now itcan bring about depression....and not the because I feel sad but more that I am frustated with what anxiety does to me and how it make me retreat to the safety of my home....but I have the strongest urge to go out and conquer it but some days can't. Where as the depression that most get is the urge to stay home and not have a desire to go out. At leat for me this is what I see to be hwo it works....but everyone's situation is very different.